901-79 Borderline Isolated Systolic Hypertension and Subsequent Risk of Cardiovascular Disease

Isolated systolic hypertension: cardiovascular risk and treatment benefits.

Mind the gap: pulse pressure, cardiovascular risk, and isolated systolic hypertension.

Hypertension is an age-old problem, and the importance of arterial blood pressure as a determinant of cardiovascular risk has been clearly demonstrated by a number of major studies since the introduction of the mercury sphygmomanometer nearly 100 years ago. Similarly, the benefits of treating hypertension have been equally well established by randomized, controlled trials. However, many of thes...

Extent of cardiovascular risk reduction associated with treatment of isolated systolic hypertension.

BACKGROUND The Systolic Hypertension in the Elderly Program (SHEP) demonstrated the benefit of treating isolated systolic hypertension (ISH) in older adults. However, nearly 20% of older adults remain at high risk of heart disease and stroke from untreated ISH. METHODS For the Pittsburgh SHEP cohort, 11- to 14-year death or cardiovascular event rates were compared for active (n = 135) and pla...

Isolated systolIc hypertensIon

Until the 1980’s the diastolic blood pressure (DBP) was assumed to be the most relevant hemodynamic parameter for prognosis of hypertensive patients. Elevated systolic pressure was considered as an inevitable consequence of aging and many physicians were reluctant to pay credence to the need for therapy of elevated systolic blood pressure. There was a radical change in thinking based on epidemi...

Treating isolated systolic hypertension prevented major cardiovascular events across strata of risk in older patients.

Patients 4736 community dwelling patients who were > 60 years of age and had ISH (systolic BP 160 to 219 mm Hg and diastolic BP < 90 mm Hg assessed and averaged over 2 visits), no atrial fibrillation, and no history of myocardial infarction (MI) or stroke in the previous 6 months. Patients taking antihypertensive medications were eligible if their BPs met the entry criteria for ISH after medica...